EAPB02303 | Microtubule inhibitor | Probechem Biochemicals

Chemical Structure : EAPB02303

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EAPB02303 (EAPB 02303)

货号: PC-20673Not For Human Use, Lab Use Only.

EAPB02303 (EAPB 02303) is a novel microtubule-disrupting agent with in-vivo activity in PDAC and in-vitro synergy with Paclitaxel, inhibits A375 melanoma cell line with IC50 of 3 nM.

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生物&药学活性

EAPB02303 (EAPB 02303) is a novel microtubule-disrupting agent with in-vivo activity in PDAC and in-vitro synergy with Paclitaxel, inhibits A375 melanoma cell line with IC50 of 3 nM.
EAPB02303 does not inhibit tubulin polymerization.
EAPB02303 exerts activity at low nanomolar concentrations in-vitro in PDAC cell lines and 3D models, and is able to reduce tumor growth in our xenografts in-vivo mouse models.
EAPB02303 is a potent synergy with Paclitaxel at lower concentrations of both compounds.
EAPB02303 induces mitosis arrest and impairment of spindle assembly.
EAPB02303 treatment reduced tumor size and weight of the A375 human melanoma xenografts in a dose-dependent manner, correlated with a low mitotic index but not with necrosis.

物理化学性质&存储条件

分子量	306.33
分子式	C17H14N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	OC1=CC=C(C2=CN=C3N2C4=C(C=CC=C4)N=C3NC)C=C1O

参考文献

1. Patinote C, et al. Eur J Med Chem. 2021 Feb 15;212:113031.

2. Deleuze-Masqeufa C. et al. WO 2009 043934A1.

3. Kevin Bigot, et al. Cancer Res (2023) 83 (7_Supplement): 5729.

EAPB02303 (EAPB 02303)

生物&药学活性

物理化学性质&存储条件

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EAPB02303 (EAPB 02303)

生物&药学活性

物理化学性质&存储条件

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