Chemical Structure : E7/PTPN14 inhibitor compound 20
CAS No.:
391869-70-8
E7/PTPN14 inhibitor compound 20
(F0470-0212 )
货号: PC-20996Not For Human Use, Lab Use Only.
E7/PTPN14 inhibitor compound 20 is a first-in-class inhibitor of PPI of HPV E7 oncoprotein and the cellular phosphatase PTPN14 (E7/PTPN14 interaction) with IC50 of 4.7 uM in ELISA-based assays, selectively affect the viability of HPV-positive cervical cancer cells.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
E7/PTPN14 inhibitor compound 20 is a first-in-class inhibitor of PPI of HPV E7 oncoprotein and the cellular phosphatase PTPN14 (E7/PTPN14 interaction) with IC50 of 4.7 uM in ELISA-based assays, selectively affect the viability of HPV-positive cervical cancer cells.
E7/PTPN14 inhibitor compound 20 remarkably affects the viability of both HPV-positive cancer cell lines with IC50 of 15.2 uM in HeLa cells and 6.6 uM in CaSki cells, without showing toxicity (IC50 > 250 μM) against either HPV-negative C33A cancer cells or non-tumoral cells.
E7/PTPN14 inhibitor compound 20 (25 uM) increases PTPN14 levels and induces the cytoplasmic relocalization and transcriptional inactivation of YAP in HPV18-positive HeLa cells.
E7/PTPN14 inhibitor compound 20 affects the proliferation, clonogenicity, migration/invasion capacity, and stem-cell survival of HPV-positive cancer cells.
E7/PTPN14 inhibitor compound 20 is active against different high-risk HPV genotypes, thus exhibiting a potential broad-spectrum activity.
物理化学性质&存储条件
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分子量
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497.47
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分子式
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C19H14F3N5O4S2
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20°C 12 个月; 4°C 6 个月
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- 配置液
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-80°C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(NC1=NN=C(SCC(NC2=CC=CC=C2C(F)(F)F)=O)S1)C3=CC=C(C)C([N+]([O-])=O)=C3
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参考文献
1. Chiara Bertagnin, et al. Cancer Lett. 2023 Jul 31;216331.
