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首页-小分子抑制剂&激动剂-Epigenetics-Histone Demethylase-E67-2
E67-2

Chemical Structure : E67-2

CAS No.: 1364914-62-4

E67-2 (KDM7A inhibitor E67-2)

货号: PC-61816Not For Human Use, Lab Use Only.

E67-2 is a potent and selective inhibitor of H3K9 Jumonji demethylase KIAA1718 (KDM7A) with IC50 of 3.4 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    E67-2 is a potent and selective inhibitor of H3K9 Jumonji demethylase KIAA1718 (KDM7A) with IC50 of 3.4 uM.
    E67-2 selectively inhibits H3K9 Jumonji demethylase over H3K9 methyltransferase as well as H3K4 demethylase, has low cytotoxicity.

    物理化学性质&存储条件

    分子量 404.559
    分子式 C21H36N6O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    7-((5-aminopentyl)oxy)-N2-(3-(dimethylamino)propyl)-6-methoxy-N4,N4-dimethylquinazoline-2,4-diamine

    参考文献

    1. Upadhyay AK, et al. J Mol Biol. 2012 Feb 24;416(3):319-27.

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