E64FC26 | pan PDI inhibitor | Probechem Biochemicals

Chemical Structure : E64FC26

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E64FC26 (PDI inhibitor E64FC26)

货号: PC-21467Not For Human Use, Lab Use Only.

E64FC26 is a potent, pan-style PDI (protein disulfide isomerase) inhibitor with IC50 of 1.9 uM (PDIA1), also inhibits all other members of the PDI family including PDIA3, PDIA4, TXNDC5, and PDIA6.

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生物&药学活性

E64FC26 is a potent, pan-style PDI (protein disulfide isomerase) inhibitor with IC50 of 1.9 uM (PDIA1), also inhibits all other members of the PDI family including PDIA3, PDIA4, TXNDC5, and PDIA6.
E64FC26 shows potent single-agent anti-MM activity with EC50 of 0.59 uM.
E64FC26 is preferentially cytotoxic to MM cell lines over normal cell types.
E64FC26 induces ER and oxidative stress in MM cells and synergistically enhances the anti-MM cytotoxic effects proteasome inhibitors (PIs).
E64FC26 improved survival and enhanced the activity of bortezomib without any adverse effects in mice with MM.

物理化学性质&存储条件

分子量	340.38
分子式	C19H23F3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1E)-1-Nonylidene-3-(trifluoromethyl)-1H-indene-5,6-diol

参考文献

1. Robinson RM, et al. Leukemia. 2019 Apr;33(4):1011-1022.

2. Hurst KE, et al. Cells. 2019 Nov 26;8(12):1514.

E64FC26 (PDI inhibitor E64FC26)

生物&药学活性

物理化学性质&存储条件

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E64FC26 (PDI inhibitor E64FC26)

生物&药学活性

物理化学性质&存储条件

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