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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-E6446
E6446

Chemical Structure : E6446

CAS No.: 1219925-73-1

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E6446 (E-6446)

货号: PC-62232Not For Human Use, Lab Use Only.

E 6446 is a novel orally available small molecule inhibitor of TLR7 and TLR9 with IC50 of 1.78 uM and 0.01 uM, respectively.

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10 mg ￥2480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

E6446 is a novel orally available small molecule inhibitor of TLR7 and TLR9 with IC50 of 1.78 uM and 0.01 uM, respectively.
E6446 shows weak activity against TLR4 (IC50=10.58 uM).
E6446 potently inhibits IL-6 production induced by CpG2216 and suppresses both IL-6 and α-interferon production induced by CpG oligo.
E6446 prevents DNA-TLR9 interaction in vitro and modulates signaling in vivo.

物理化学性质&存储条件

分子量 449.595
分子式 C27H35N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(3-Pyrrolidin-1-yl-propoxy)-2-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-benzooxazole

参考文献

1. Lamphier M, et al. Mol Pharmacol. 2014 Mar;85(3):429-40.

2. Franklin BS, et al. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94.

3. Dias AA, et al. J Immunol. 2016 Sep 1;197(5):1905-13.

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