E6060 | RARα agonist | Probechem Biochemicals

Chemical Structure : E6060

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E6060 (E 6060)

货号: PC-21837Not For Human Use, Lab Use Only.

E6060 is a potent, selective retinoic acid receptor subtype α (RAR-α) agonist with Ki of 0.2 nM, IC50 of 0.2 nM for RAR-α-mediated reporter transactivation assays.

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生物&药学活性

E6060 is a potent, selective retinoic acid receptor subtype α (RAR-α) agonist with Ki of 0.2 nM, IC50 of 0.2 nM for RAR-α-mediated reporter transactivation assays.
E6060 does not induce reporter transactivation through any of the RXR homodimers (RXR-α, RXR-β, and RXR-γ) at 3000 nM.
E6060 at 0.03 and 0.1 mg/kg (once daily, p.o.) significantly improved survival rate and prevented the development of proteinuria in (NZBxNZW)F1 mice.
E6060 also reduced anti-DNA autoantibodies and total serum IgG in E6060-treated mice.

物理化学性质&存储条件

分子量	389.31
分子式	C20H11F4NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-{5-[7-fluoro-4-(trifluoromethyl)benzo[b]furan-2-yl]-1H-2-pyrrolyl}benzoic acid

参考文献

1. Yamauchi T, et al. J Pharmacol Exp Ther. 2005 Mar;312(3):938-44.

E6060 (E 6060)

生物&药学活性

物理化学性质&存储条件

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E6060 (E 6060)

生物&药学活性

物理化学性质&存储条件

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