E567 | TLR2 inhibitor | Probechem Biochemicals

Chemical Structure : E567

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E567 (TLR2 inhibitor E567)

货号: PC-49127Not For Human Use, Lab Use Only.

E567 is a small molecule TLR2 signaling inhibitor with anti-viral activity, efficiently inhibits both LCMV and HSV-1 induced cytokine responses in both human and mouse cell cultures.

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生物&药学活性

E567 is a small molecule TLR2 signaling inhibitor with anti-viral activity, efficiently inhibits both LCMV and HSV-1 induced cytokine responses in both human and mouse cell cultures.
E567 down-regulates TLR2 expression, and blocks LCMV-induced TLR2-mediated NF-κB activity and production of IL-8 in HEK cells, does not affect TNF-α-induced expression of TLR2.
E567 inhibits LCMV-induced TLR2 expression and LCMV replication in HEK293 cells.
E567 inhibits both LCMV and HSV induced cytokine responses in primary mouse macrophages.
E567 inhibits both LCMV and HSV-1-induced RANTES and IL8 production in mouse primary macrophages.
E567 (16 mg/kg) blocks LCMV and other TLR ligands induced inflammation, also significantly blocks both TLR2 ligand Pam2CSK4 and TLR4 ligand LPS induced IL-6 and MCP-1 production in vivo.

物理化学性质&存储条件

分子量	378.476
分子式	C22H26N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(benzo[d]isoxazol-3-ylmethyl)-3-(4-((4-methylpiperidin-1-yl)methyl)phenyl)urea

参考文献

1. Shenghua Zhou, et al. Antiviral Res. 2010 Sep;87(3):295-306.

E567 (TLR2 inhibitor E567)

生物&药学活性

物理化学性质&存储条件

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E567 (TLR2 inhibitor E567)

生物&药学活性

物理化学性质&存储条件

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