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首页-小分子抑制剂&激动剂-Others-Other Targets-E260
E260

Chemical Structure : E260

CAS No.: 1241537-79-0

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E260 (E 260)

货号: PC-62649Not For Human Use, Lab Use Only.

E260 is a novel inhibitor of the Fer/FerT kinase with Kd of 0.85 uM, selectively evokes metabolic stress and necrotic death in cancer cells.

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10 mg ￥2880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

E260 is a novel inhibitor of the Fer/FerT kinase with Kd of 0.85 uM, selectively evokes metabolic stress and necrotic death in cancer cells.
E260 compromises mitochondrial integrity, and activates PARP-1 and autophagy, thereby targeting the energy management system of cancer cells.
E260 exhibits an viability EC50 of 400 nM after 24 h of treatment and an EC50 of 300 nM after 48 h in metastatic SW620 cells.
E260 suppresses xenografts progression in vivo.

物理化学性质&存储条件

分子量 438.638
分子式 C24H34N6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(4-isopropylphenyl)-2-(4-((4-methylpiperazin-1-yl)methyl)piperidin-1-yl)imidazo[2,1-b][1,3,4]thiadiazole

参考文献

1. Elkis Y, et al. Nat Commun. 2017 Oct 16;8(1):940.

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