E0924G | Osteoprotegerin upregulator, PPARδ activator

Chemical Structure : E0924G

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E0924G (E 0924G)

货号: PC-22205Not For Human Use, Lab Use Only.

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25 mg		Get quote
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250 mg		Get quote

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生物&药学活性

E0924G is a small molecule osteoprotegerin (OPG, EC50=0.29 uM) and runt-related transcription factor 2 (RUNX2) upregulator, effectively promotes osteogenesis and inhibits osteoclastogenesis through activating the PPARδ signaling pathway.
E0924G upregulates OPG expression in osteoprotegerin (OPG) with EC50 of 0.29 uM based on an established UOP cell model stably transfected with pGL4.17-OPGp.
E0924G significantly increases the protein levels of the osteoblast markers OPG, BMP2, and RUNX2 in a dose-dependent manner.
E0924G inhibits RANKL-induced osteoclast differentiation and bone resorption.
E0924G (5 mg/kg, 20 mg/kg, 0.5 % CMC-Na) attenuates bone loss in ovariectomized (OVX) rats, prevents bone loss in OVX rat model of osteoporosis.
E0924G attenuates bone loss in senescence-accelerated mouse prone 6 (SAMP6) mice, promotes bone formation and inhibits bone resorption.
E0924G promotes osteogenic differentiation and inhibits osteoclast differentiation through activating PPARδ.

物理化学性质&存储条件

分子量	232.24
分子式	C12H12N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-methoxypyridin-2-yl)-5-methylfuran-2-carboxamide

参考文献

1. Yining Li, et al. Bioorg Chem. 2024 Apr 11:147:107364.

E0924G (E 0924G)

生物&药学活性

物理化学性质&存储条件

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E0924G (E 0924G)

生物&药学活性

物理化学性质&存储条件

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