E-7386 | CBP/beta-catenin inhibitor | Probechem Biochemicals

Chemical Structure : E-7386

CAS No.: 1799824-08-0

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E-7386 (E7386)

货号: PC-35329Not For Human Use, Lab Use Only.

E-7386 (E7386) is a potent, orally active modulator of CBP/beta-catenin, disrupts the interaction and inhibits canonical Wnt signaling pathway /TCF reporter gene activity in LiCl-stimulated HEK-293 and MDA-MB-231 with IC50 of 55 and 73 nM, respectively.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2380	In stock
25 mg	￥3780	In stock
50 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

E-7386 (E7386) is a potent, orally active modulator of CBP/beta-catenin, disrupts the interaction and inhibits canonical Wnt signaling pathway /TCF reporter gene activity in LiCl-stimulated HEK-293 and MDA-MB-231 with IC50 of 55 and 73 nM, respectively.
E7386 exhibits anti-tumor activity in vitro tumor proliferation panel against 28 human tumor cell lines.
E7386 modulates the expression of Wnt signaling pathway related genes including AXIN2 and other genes, significantly suppressed the number of polyposis in a dose dependent manner at the dose 8.5-50 mg/kg, also significantly changed the expressions of Wnt related genes in whisker follicle of ApcMin/+mice model.

物理化学性质&存储条件

分子量	725.87
分子式	C39H48FN9O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(6S,9aS)-2-allyl-N-benzyl-8-((6-(3-(4-ethylpiperazin-1-yl)azetidin-1-yl)pyridin-2-yl)methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxohexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide

参考文献

1. Kazuhiko Yamada, et al. Abstract 5177: E7386 : First-in-class orally active CBP/beta-catenin modulator as an anticancer agent. AACR 2017.

E-7386 (E7386)

生物&药学活性

物理化学性质&存储条件

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E-7386 (E7386)

生物&药学活性

物理化学性质&存储条件

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