Dynole 34-2 |CAS:1128165-88-7 Probechem Biochemicals

Chemical Structure : Dynole 34-2

CAS No.: 1128165-88-7

加入收藏

Dynole 34-2 (Dynamin GTPase inhibitor)

货号: PC-63240Not For Human Use, Lab Use Only.

Dynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Dynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively.
Dynole 34-2 induces cytokinesis failure at the point of abscission, consistent with inhibition of dynamin while not affecting other cell cycle stages in cancer cell.
Dynole 34-2 disrupt midbody localization of calcineurin but not phospho-dynII and γ-tubulin, inhibits growth in a range of cancer cell lines with IC50 of 4.0 to 36.7 uM in MTT assays.
Dynole 34-2 is a novel antimitotic compound acting specifically at the abscission stage.

物理化学性质&存储条件

分子量	408.59
分子式	C25H36N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide

参考文献

1. Chircop M, et al. Mol Cancer Ther. 2011 Sep;10(9):1553-62.

2. Hill TA, et al. J Med Chem. 2009 Jun 25;52(12):3762-73.

3. Robertson MJ, et al. Nat Protoc. 2014 Apr;9(4):851-70.

4. Jackson J, et al. Mol Psychiatry. 2015 Jul;20(7):810-9.

Dynole 34-2 (Dynamin GTPase inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Dynole 34-2 (Dynamin GTPase inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.