Dynein2-IN-37 |CAS:1823133-56-7 Probechem Biochemicals

Chemical Structure : Dynein2-IN-37

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Dynein2-IN-37 (Ciliobrevin analog 37)

货号: PC-62397Not For Human Use, Lab Use Only.

Dynein2-IN-37 (Ciliobrevin analog 37) is a potent, selective cytoplasmic dynein 2 ATPase activity antagonist with IC50 of 11 uM, shows weak inhibition for dynein 2 (IC50=280 uM).

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生物&药学活性

Dynein2-IN-37 (Ciliobrevin analog 37) is a potent, selective cytoplasmic dynein 2 ATPase activity antagonist with IC50 of 11 uM, shows weak inhibition for dynein 2 (IC50=280 uM).
Dynein2-IN-37 directly targets the heavy chains of both dynein isoforms and explore the structure-activity landscape of these inhibitors in vitro and in cells.
Dynein2-IN-37 inhibits retrograde ciliary GLI2 transport more strongly than ciliobrevin A, effectively disrupts Hedgehog signaling, intraflagellar transport, and ciliogenesis.

物理化学性质&存储条件

分子量	478.329
分子式	C25H17Cl2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2,4-dichlorophenyl)-2-(7-(4-methylbenzyloxy)-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-oxopropanenitrile

参考文献

1. See SK, et al. ACS Chem Biol. 2016 Jan 15;11(1):53-60.

Dynein2-IN-37 (Ciliobrevin analog 37)

生物&药学活性

物理化学性质&存储条件

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Dynein2-IN-37 (Ciliobrevin analog 37)

生物&药学活性

物理化学性质&存储条件

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