Dynasore | Dynamin inhibitor | Probechem Biochemicals

Chemical Structure : Dynasore

CAS No.: 304448-55-3

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Dynasore (Dynamin inhibitor)

货号: PC-20700Not For Human Use, Lab Use Only.

Dynasore is a specific, cell-permeable inhibitor of dynamin GTPase function, acts as a potent inhibitor of endocytic pathways known to depend on dynamin by rapidly blocking coated vesicle formation.

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生物&药学活性

Dynasore is a specific, cell-permeable inhibitor of dynamin GTPase function, acts as a potent inhibitor of endocytic pathways known to depend on dynamin by rapidly blocking coated vesicle formation.
Dynasore interferes in vitro with the GTPase activity of dynamin1, dynamin2, and Drp1, the mitochondrial dynamin, but not of other small GTPases.
Dynasore inhibits the GTPase activity of full-length dynamin1 or dynamin2 ΔPRD stimulated by self-association in a dose-dependent manner with IC50 of 15 uM.
Dynasore blocks clathrin-mediated endocytosis in nonneuronal cells, reversibly blocks endocytosis in hippocampal synapses.
Dynasore has no immediate effect on exocytosis.

物理化学性质&存储条件

分子量	322.32
分子式	C18H14N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Hydroxynaphthalene-2-carboxylicacid(3,4-dihydroxybenzylidene)hydrazide

参考文献

1. Macia E, et al. Dev Cell. 2006 Jun;10(6):839-50.

2. Newton AJ, et al. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17955-60.

Dynasore (Dynamin inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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Dynasore (Dynamin inhibitor)

生物&药学活性

物理化学性质&存储条件

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