Dynarrestin | Dynein inhibitor | Probechem Biochemicals

Chemical Structure : Dynarrestin

CAS No.: 2222768-84-3

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Dynarrestin (Dynein inhibitor)

货号: PC-62399Not For Human Use, Lab Use Only.

Dynarrestin is a novel inhibitor of cytoplasmic Dyneins 1 and 2, acts reversibly to inhibit cytoplasmic dynein 1-dependent microtubule binding and motility in vitro without affecting ATP hydrolysis.

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25 mg	￥2180	In stock
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生物&药学活性

Dynarrestin is a novel inhibitor of cytoplasmic Dyneins 1 and 2, acts reversibly to inhibit cytoplasmic dynein 1-dependent microtubule binding and motility in vitro without affecting ATP hydrolysis.
Dynarrestin rapidly and reversibly inhibits endosome movement in living cells and perturbs mitosis by inducing spindle misorientation and pseudoprometaphase delay.
Dynarrestin reversibly inhibits cytoplasmic dynein 2-dependent intraflagellar transport (IFT) of the cargo IFT88 and flux of Smo within cilia without interfering with ciliogenesis and suppresses Hh-dependent proliferation of neuronal precursors and tumor cells.

物理化学性质&存储条件

分子量	431.502
分子式	C22H23F2N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate

参考文献

1. Höing S, et al. Cell Chem Biol. 2018 Jan 26. pii: S2451-9456(17)30463-4.

Dynarrestin (Dynein inhibitor)

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物理化学性质&存储条件

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Dynarrestin (Dynein inhibitor)

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物理化学性质&存储条件

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