Duvelisib (IPI-145, INK-1197)

Chemical Structure : Duvelisib

CAS No.: 1201438-56-3

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货号: PC-45169Not For Human Use, Lab Use Only.

Duvelisib (IPI-145, INK-1197) is a potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM.

规格	价格	库存
5 mg	￥980	In stock
25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg	￥4580	In stock
250 mg		Get quote

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生物&药学活性

Duvelisib (IPI-145, INK-1197) is a potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM.
Duvelisib (IPI-145, INK-1197) displays high selectivity for PI3K δ/γ than other protein kinases.
Duvelisib (IPI-145, INK-1197) exerts profound effects on adaptive and innate immunity by inhibiting B and T cell proliferation, blocking neutrophil migration, and inhibiting basophil activation.
Duvelisib (IPI-145, INK-1197) exhibits potent activity in collagen-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus rodent models.

物理化学性质&存储条件

分子量	416.863
分子式	C22H17ClN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 41 mg/mL
Chemical Name/SMILES	1(2H)-Isoquinolinone, 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-

参考文献

1. Winkler DG, et al. Chem Biol. 2013 Nov 21;20(11):1364-74.

2. Boyle DL, et al. J Pharmacol Exp Ther. 2014 Feb;348(2):271-80.

3. Dong S, et al. Blood. 2014 Dec 4;124(24):3583-6.