Dutacatib (AFG495) | Cathepsin K inhibitor | Probechem Biochemicals

Chemical Structure : Dutacatib

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Dutacatib (AFG495, AFG-495)

货号: PC-20203Not For Human Use, Lab Use Only.

Dutacatib (AFG495) is potent, selective and non-covalent cathepsin K inhibitor with IC50 of 3-6 nM (human CatK), shows excellent selectivity profile versus human cathepsins L and S.

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生物&药学活性

Dutacatib (AFG495) is potent, selective and non-covalent cathepsin K inhibitor with IC50 of 3-6 nM (human CatK), shows excellent selectivity profile versus human cathepsins L and S.

物理化学性质&存储条件

分子量	421.55
分子式	C23H31N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[[2-cyano-4-(2,2-dimethylpropylamino)pyrimidin-5-yl]methyl]-4-(4-methylpiperazin-1-yl)benzamide

参考文献

1. Eva Altmann, et al. J Med Chem. 2002 Jun 6;45(12):2352-4.

Dutacatib (AFG495, AFG-495)

生物&药学活性

物理化学性质&存储条件

参考文献

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Dutacatib (AFG495, AFG-495)

生物&药学活性

物理化学性质&存储条件

参考文献

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