Chemical Structure : Durvalumab
CAS No.: 1428935-60-7
货号: PC-Ab1055Not For Human Use, Lab Use Only.
Durvalumab (MEDI-4736) is a human immunoglobulin G1 kappa monoclonal antibody that binds to PD-L1 and blocks the interaction of PD-L1 with programmed cell death protein 1 (PD-1) and CD80 (B7.1). Blockade of PD-L1/PD-1 and PD-L1/CD80 interactions releases the inhibition of immune responses, without inducing antibody dependent cell-mediated cytotoxicity..
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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Durvalumab (MEDI-4736) is a human immunoglobulin G1 kappa monoclonal antibody that binds to PD-L1 and blocks the interaction of PD-L1 with programmed cell death protein 1 (PD-1) and CD80 (B7.1). Blockade of PD-L1/PD-1 and PD-L1/CD80 interactions releases the inhibition of immune responses, without inducing antibody dependent cell-mediated cytotoxicity.
分子量 | ||
分子式 | Human IgG1-Kappa | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Durvalumab;Anti-PD-L1 monoclonal antibody; Anti-PD-LI mAb; Anti-programmed cell death 1 ligand 1 monoclonal antibody; Imfimzi; Imfinzi; MEDI-4736; 1428935-60-7 |
1. 1, Stewart R, et al. Cancer Immunol Res. 2015 Sep;3(9):1052-62. 2, Naidoo J, et al. Cancer Immunol Res. 2016 May;4(5):383-9. 3, Massard C, et al. J Clin Oncol. 2016 Sep 10;34(26):3119-25. 4, Antonia SJ, et al. N Engl J Med. 2017 Nov 16;377(20):1919-1929. 5, Voudouri D, et al. Curr Probl Cancer. 2017 Nov-Dec;41(6):407-412.
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