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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Durlobactam sodium
Durlobactam sodium

Chemical Structure : Durlobactam sodium

CAS No.: 1467157-21-6

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Durlobactam sodium (ETX-2514, ETX2514)

货号: PC-20706Not For Human Use, Lab Use Only.

Durlobactam (ETX2514) sodium is a broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A β-lactamase KPC-2, class AmpC and class D OXA-24, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Durlobactam (ETX2514) sodium is a broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A β-lactamase KPC-2, class AmpC and class D OXA-24, respectively.
Durlobactam (ETX2514) potently inhibits clinically relevant class A, C and D β-lactamases and penicillin-binding proteins, resulting in intrinsic antibacterial activity against Enterobacteriaceae and restoration of β-lactam activity in a broad range of MDR Gram-negative pathogens.
Combination of sulbactam and ETX2514 shows potent antibacterial activity, in vivo efficacy against MDR A. baumannii infections.
Durlobactam (ETX2514) restores sulbactam activity against resistant Acinetobacter baumannii.

物理化学性质&存储条件

分子量 299.23
分子式 C8H10N3NaO6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Sodium (1R,2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl sulfate

参考文献

1. Durand-Réville TF, et al. Nat Microbiol. 2017 Jun 30;2:17104.

2. McLeod SM, et al. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01576-17.

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