Dual Hsp90-HDAC6 inhibitor 17

Chemical Structure : Dual Hsp90-HDAC6 inhibitor 17

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货号: PC-25122Not For Human Use, Lab Use Only.

Dual Hsp90/HDAC6 inhibitor 17 is a potent, selective dual Hsp90/HDAC6 inhibitor with IC50 of 28/96 nM respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

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生物&药学活性

Dual Hsp90/HDAC6 inhibitor 17 is a potent, selective dual Hsp90/HDAC6 inhibitor with IC50 of 28/96 nM respectively.
Compound 17 is 107- to 430-fold more potent on HDAC6 compared to class I HDACs and 18- to 96-fold more potent compared to class IIa HDACs.
Compound 17 is also 4 times more active on HDAC6 than HDAC11 and 29 times more active than HDAC10.
Compound 17 demonstrates cell growth inhibitory activity with GI50 of 0.7, 2.2 and 0.8 uM for LNCaP, PC3, and DU145 cancer cells.
Compound 17 demonstrated marked anticancer activity and ability to target both established tumor masses and tumor-initiating cell populations in 3D tumor spheroid models.

物理化学性质&存储条件

分子量	466.93
分子式	C23H23ClN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((2-Amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)-N-hydroxybenzamide

参考文献

1. Citarella A, et al. J Med Chem. 2025 Jul 23. doi: 10.1021/acs.jmedchem.5c00717.