Droxinostat |CAS:99873-43-5 Probechem Biochemicals

Chemical Structure : Droxinostat

CAS No.: 99873-43-5

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Droxinostat (NS 41080;NS-41080;NS41080)

货号: PC-43447Not For Human Use, Lab Use Only.

Droxinostat (NS-41080) is a selective HDAC inhibitor with IC50 of 16.9, 2.47 and 1.46 uM for HDAC3, HDAC6 and HDAC8, respectively.

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5 mg (Free Sample)	￥180	In stock
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg		Get quote

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生物&药学活性

Droxinostat (NS-41080) is a selective HDAC inhibitor with IC50 of 16.9, 2.47 and 1.46 uM for HDAC3, HDAC6 and HDAC8, respectively.
Droxinostat (NS-41080) does not inhibit HDAC1, HDAC2, HDAC4, HDAC5, HDAC7, HDAC9, and HDAC10 with IC50 of >20 uM.
Droxinostat (NS-41080) sensitizes malignant cells to death receptor ligands FAS and TRAIL sensitization with IC50 of 20 and 39 uM, respectively.
Droxinostat (NS-41080) decreases the expression of the caspase-8 inhibitor FLIP, downregulates c-FLIP(L) and c-FLIP(S) mRNA and protein levels, causes PARP degradation, reduces cell survival, and induces apoptosis in MCF-7 breast cancer cells.

物理化学性质&存储条件

分子量	243.69
分子式	C11H14ClNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Butanamide, 4-(4-chloro-2-methylphenoxy)-N-hydroxy-

参考文献

1. Wood TE, et al. Mol Cancer Ther. 2010 Jan;9(1):246-56.

2. Bijangi-Vishehsaraei K, et al. Mol Cell Biochem. 2010 Sep;342(1-2):133-142.

3. McCourt C, et al. Clin Cancer Res. 2012 Jul 15;18(14):3822-33.

4. Liu J, et al. Transl Oncol. 2016 Feb;9(1):70-78.

Droxinostat (NS 41080;NS-41080;NS41080)

生物&药学活性

物理化学性质&存储条件

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Droxinostat (NS 41080;NS-41080;NS41080)

生物&药学活性

物理化学性质&存储条件

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