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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Estrogen Receptor/ERR-Droloxifene
Droloxifene

Chemical Structure : Droloxifene

CAS No.: 82413-20-5

Droloxifene (3-Hydroxytamoxifen;FK-435)

货号: PC-70133Not For Human Use, Lab Use Only.

Droloxifene (3-Hydroxytamoxifen; FK-435) is a nonsteroidal selective estrogen receptor modulator (SERM) that shows 10- to 60-fold increased affinity for the estrogen receptor compared with Tamoxifen.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Droloxifene (3-Hydroxytamoxifen; FK-435) is a nonsteroidal selective estrogen receptor modulator (SERM) that shows 10- to 60-fold increased affinity for the estrogen receptor compared with Tamoxifen.
Droloxifene has reduced partial estrogen agonistic activity.

物理化学性质&存储条件

分子量 387.52
分子式 C26H29NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(Z)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol

参考文献

1. Rauschning W, et al. Breast Cancer Res Treat. 1994;31(1):83-94.

2. Hasmann M, et al. Cancer Lett. 1994 Sep 15;84(2):101-16.

3. Leng Y, et al. Eur J Pharmacol. 2000 Dec 8;409(2):123-31.

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