Dovitinib lactate (CHIR-258, TKI-258) |CAS:692737-80-7 Probechem Biochemicals

Chemical Structure : Dovitinib lactate

CAS No.: 692737-80-7

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Dovitinib lactate (CHIR-258, TKI258, TKI-258, CHIR258)

货号: PC-42452Not For Human Use, Lab Use Only.

Dovitinib lactate (CHIR-258, TKI-258) is a multitargeted RTK inhibitor of class III, IV, and V RTKs with IC50 of 1/2/36/8/9 nM for FLT3/c-KIT/c-Fms/FGFR1/FGFR3, respectively.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg	￥3880	In stock
250 mg		Get quote

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生物&药学活性

Dovitinib lactate (CHIR-258, TKI-258) is a multitargeted RTK inhibitor of class III, IV, and V RTKs with IC50 of 1/2/36/8/9 nM for FLT3/c-KIT/c-Fms/FGFR1/FGFR3, respectively.
Dovitinib also inhibits VEGFR1/2/3 (IC50=10/13/8 nM) and PDGFRβ/α (IC50=27/210 nM).
Dovitinib selectively inhibits the growth of B9 cells and human myeloma cell lines expressing wild-type (WT) or activated mutant FGFR3.
Dovitinib inhibits downstream ERK 1/2 phosphorylation and induces cytostatic and cytotoxic effects.
Dovitinib demonstrates activity in a xenograft mouse model of FGFR3 MM; orally active.

物理化学性质&存储条件

分子量	482.5073832
分子式	C24H27FN6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	Propanoic acid, 2-hydroxy-, compd. with 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone (1:1)

参考文献

1. Trudel S, et al. Blood. 2005 Apr 1;105(7):2941-8.

2. Lopes de Menezes DE, et al. Clin Cancer Res. 2005 Jul 15;11(14):5281-91.

3. Xin X, et al. Clin Cancer Res. 2006 Aug 15;12(16):4908-15.

Dovitinib lactate (CHIR-258, TKI258, TKI-258, CHIR258)

生物&药学活性

物理化学性质&存储条件

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Dovitinib lactate (CHIR-258, TKI258, TKI-258, CHIR258)

生物&药学活性

物理化学性质&存储条件

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