Dorsomorphin dihydrochloride
(BML-275 dihydrochloride, Compound C dihydrochloride, BML275 dihydrochloride)
货号: PC-43521Not For Human Use, Lab Use Only.
Dorsomorphin (BML-275, Compound C) is a potent, selective and reversible AMPK inhibitor with Ki of 109 nM, shows no no significant activity on ZAPK, SYK, PKCθ, PKA and JAK3.
Dorsomorphin (BML-275, Compound C) dihydrochloride is a potent, selective and reversible AMPK inhibitor with Ki of 109 nM, shows no no significant activity on ZAPK, SYK, PKCθ, PKA and JAK3.
Dorsomorphin inhibits AMPK activation induced by AICAR and Metformin, also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6).
Dorsomorphin promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro, induces autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.
