Dorsomorphin (BML-275) | AMPK inhibitor | Probechem Biochemicals

Chemical Structure : Dorsomorphin

CAS No.: 866405-64-3

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Dorsomorphin (BML-275, Compound C, BML275)

货号: PC-43522Not For Human Use, Lab Use Only.

Dorsomorphin (BML-275, Compound C) is a potent, selective and reversible AMPK inhibitor with Ki of 109 nM, shows no no significant activity on ZAPK, SYK, PKCθ, PKA and JAK3.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

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生物&药学活性

Dorsomorphin (BML-275, Compound C) is a potent, selective and reversible AMPK inhibitor with Ki of 109 nM, shows no no significant activity on ZAPK, SYK, PKCθ, PKA and JAK3.
Dorsomorphin (BML-275, Compound C) inhibits AMPK activation induced by AICAR and Metformin, also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6).
Dorsomorphin (BML-275, Compound C)promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro, induces autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.

物理化学性质&存储条件

分子量	399.49
分子式	C24H25N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-

参考文献

1. Yu PB, et al. Nat Chem Biol. 2008 Jan;4(1):33-41.

2. Vucicevic L, et al. Autophagy. 2011 Jan;7(1):40-50.

3. Diekmann U, et al. Stem Cells Dev. 2015 Jan 15;24(2):190-204.

4. Zhou G, et al. J Clin Invest. 2001 Oct;108(8):1167-74.

Dorsomorphin (BML-275, Compound C, BML275)

生物&药学活性

物理化学性质&存储条件

参考文献

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Dorsomorphin (BML-275, Compound C, BML275)

生物&药学活性

物理化学性质&存储条件

参考文献

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