Doravirine |CAS:1338225-97-0 Probechem Biochemicals

Chemical Structure : Doravirine

CAS No.: 1338225-97-0

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Doravirine (MK-1439;MK1439)

货号: PC-45074Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4580	In stock
100 mg		Get quote

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生物&药学活性

Doravirine (MK-1439, MK1439) is a novel, highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 12, 9.7, and 9.7 nM against WT, K103N, and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay.
Doravirine (MK-1439) shows excellent potency in suppressing the replication of WT virus with EC95 of 20 nM, as well as K103N, Y181C, and K103N/Y181C mutant viruses with EC95 of 43, 27, and 55 nM, respectively.

物理化学性质&存储条件

分子量	425.7491
分子式	C17H11ClF3N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	Benzonitrile, 3-chloro-5-[[1-[(4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]-

参考文献

1. Lai MT, et al. Antimicrob Agents Chemother. 2014;58(3):1652-63.

2. Côté B, et al. Bioorg Med Chem Lett. 2014 Feb 1;24(3):917-22.

3. Feng M, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):590-8.

Doravirine (MK-1439;MK1439)

生物&药学活性

物理化学性质&存储条件

参考文献

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Doravirine (MK-1439;MK1439)

生物&药学活性

物理化学性质&存储条件

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