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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Piezo Channel-Dooku1
Dooku1

Chemical Structure : Dooku1

CAS No.: 2253744-54-4

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Dooku1 (Dooku 1)

货号: PC-63441Not For Human Use, Lab Use Only.

Dooku1 is a Yoda1 analogue that antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation, lacks agonist activity.

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50 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: 98.53% (LCMS) Select Batch:

生物&药学活性

Dooku1 is a Yoda1 analogue that antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation, lacks agonist activity.
Dooku1 inhibits 2 μM Yoda1-induced Ca2+ -entry with IC50 of 1.3 μM (HEK 293 cells) and 1.5 μM (HUVECs) yet failed to inhibit constitutive Piezo1 channel activity.
Dooku1 has no effect on endogenous ATP-evoked Ca2+ elevation or store-operated Ca2+ entry in HEK 293 cells or Ca2+ entry through TRPV4 or TRPC4 channels overexpressed in CHO and HEK 293 cells.

物理化学性质&存储条件

分子量 326.195
分子式 C13H9Cl2N3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((2,6-dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole

参考文献

1. Evans EL, et al. Br J Pharmacol. 2018 May;175(10):1744-1759.

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