Donecopride | 5-HT4R agonist, AChE inhibitor | Probechem Biochemicals

Chemical Structure : Donecopride

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Donecopride (MR31147)

货号: PC-23390Not For Human Use, Lab Use Only.

Donecopride (MR31147) is a potent, dual serotonin subtype 4 receptor (5-HT4) agonist/acetylcholinesterase (AChE) inhibitor with Ki of 8.5 nM (5-HT4eR) and IC50 of 16 nM (hAChE).

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生物&药学活性

Donecopride (MR31147) is a potent, dual serotonin subtype 4 receptor (5-HT4) agonist/acetylcholinesterase (AChE) inhibitor with Ki of 8.5 nM (5-HT4eR) and IC50 of 16 nM (hAChE).
Donecopride is a potent, selective, and partial (h)5-HT4eR agonist.
Donecopride promotes sAPPα secretion in an in vitro cellular model to a similar degree as RS67333.
Donecopride exhibits a significant procognitive effect during the object recognition task.

物理化学性质&存储条件

分子量	392.97
分子式	C22H33ClN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one

参考文献

1. Rochais C, et al. Eur J Med Chem. 2024 Oct 18;280:116975.

2. Rochais C, et al. Br J Pharmacol. 2020 May;177(9):1988-2005.

3. Rochais C, et al. J Med Chem. 2015 Apr 9;58(7):3172-87.

4. Lecoutey C, et al. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3825-30.

Donecopride (MR31147)

生物&药学活性

物理化学性质&存储条件

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Donecopride (MR31147)

生物&药学活性

物理化学性质&存储条件

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