Divertin | MLCK1 inhibitor | Probechem Biochemicals

Chemical Structure : Divertin

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Divertin (NSC55937, Tetraformaltrisazine)

货号: PC-22342Not For Human Use, Lab Use Only.

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生物&药学活性

Divertin (NSC55937, Tetraformaltrisazine) a small molecule MLCK1 inhibitor, diverts MLCK1 from the PAMR, does not interfere with MLCK enzymatic activity, prevent MLCK-mediated intestinal barrier loss in vitro and in vivo.
Divertin restore barrier function in spontaneous colitis, and attenuate experimental, immune-mediated colitis.
Divertin reverses TNF-induced MLC phosphorylation and barrier loss in vitro.
Divertin prevents acute TNF-induced MLC phosphorylation, barrier loss, and diarrhea in vivo.
Divertin prevents TNF-induced MLCK1 trafficking, MLC phosphorylation, and tight junction reorganization in human jejunal mucosae ex vivo.
Divertin corrects intestinal permeability defects and limits progression of experimental inflammatory bowel disease.

物理化学性质&存储条件

分子量	144.18
分子式	C4H12N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,2,3,4,6,7,8,9-octahydro-[1,2,4,5]tetrazino[1,2-a][1,2,4,5]tetrazine

参考文献

1. Tang H, et al. Discov Oncol. 2024 May 12;15(1):159.

2. Graham WV, et al. Nat Med. 2019 Apr;25(4):690-700.

Divertin (NSC55937, Tetraformaltrisazine)

生物&药学活性

物理化学性质&存储条件

参考文献

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Divertin (NSC55937, Tetraformaltrisazine)

生物&药学活性

物理化学性质&存储条件

参考文献

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