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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aldehyde Dehydrogenase (ALDH)-Disulfiram
Disulfiram

Chemical Structure : Disulfiram

CAS No.: 97-77-8

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Disulfiram (Tetraethylthiuram disulfide, TETD)

货号: PC-22705Not For Human Use, Lab Use Only.

Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1) with IC50 of 0.13 uM for ALDH1A1 and 3.4 uM for ALDH2, also inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1) with IC50 of 0.13 uM for ALDH1A1 and 3.4 uM for ALDH2, also inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells.

物理化学性质&存储条件

分子量 296.52
分子式 C10H20N2S4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Bis(diethylthiocarbamoyl) disulfide

参考文献

1. Lipsky J.J., et al. Chem. Biol. Interact. 2001;130–132:93–102.

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