Diprovocim | TLR1/TLR2 agonist | Probechem Biochemicals

Chemical Structure : Diprovocim

CAS No.: 2170867-89-5

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Diprovocim (TLR1/TLR2 agonist)

货号: PC-35621Not For Human Use, Lab Use Only.

Diprovocim is a potent Toll-like receptor TLR1/TLR2 agonist that induces dose-dependent TNF production with EC50 of 110 pM in human THP-1 cells and 1.3 nM in primary mouse peritoneal macrophages.

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10 mg	￥2480	In stock
25 mg	￥4280	In stock
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生物&药学活性

Diprovocim is a potent Toll-like receptor TLR1/TLR2 agonist that induces dose-dependent TNF production with EC50 of 110 pM in human THP-1 cells and 1.3 nM in primary mouse peritoneal macrophages.
Diprovocim induces TNF production in bone marrow-derived dendritic cells (BMDC) with EC50 of 6.7 nM, also induces IL-6 production by mouse BMDC.
Diprovocim induces phosphorylation of IKKα, IKKβ, p38, JNK, and ERK, as well as degradation of IκBα in THP-1 cells and mouse peritoneal macrophages, activates conventional TLR1/TLR2 signaling, including MAPK and canonical NF-κB signaling.
Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice.

物理化学性质&存储条件

分子量	909.1
分子式	C56H56N6O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,3'S,4S,4'S)-1,1'-terephthaloylbis(N3,N4-bis((1S,2R)-2-phenylcyclopropyl)pyrrolidine-3,4-dicarboxamide)

参考文献

1. Wang Y, et al. Proc Natl Acad Sci U S A. 2018 Aug 27. pii: 201809232.

Diprovocim (TLR1/TLR2 agonist)

生物&药学活性

物理化学性质&存储条件

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Diprovocim (TLR1/TLR2 agonist)

生物&药学活性

物理化学性质&存储条件

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