Diprovocim-X | TLR1/TLR2 agonist | Probechem Biochemicals

Chemical Structure : Diprovocim-X

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Diprovocim-X (Diprovocim X)

货号: PC-47088Not For Human Use, Lab Use Only.

Diprovocim-X is a potent human and murine TLR1/TLR2 agonist with EC50 of 0.14 nM (hTLR1/TLR2) and 0.75 nM (m TLR1/TLR2), respectively.

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生物&药学活性

Diprovocim-X is a potent human and murine TLR1/TLR2 agonist with EC50 of 0.14 nM (hTLR1/TLR2) and 0.75 nM (m TLR1/TLR2), respectively.
Diprovocim-X exhibits the excellent potency/efficacy of diprovocim-1 in human cells, displays substantially improved potency/efficacy in mouse macrophages, and serves as an adjuvant in mice when coadministered with a nonimmunogenic antigen.

物理化学性质&存储条件

分子量	1134.429
分子式	C66H83N7O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 12-[[[(3S,4S)-1-[4-[[(3S,4S)-3,4-bis[[[(1S,2R)-2-phenylcyclopropyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]benzoyl]-4-[[[(1S,2R)-2-phenylcyclopropyl]amino]carbonyl]-3-pyrrolidinyl]carbonyl]amino]dodecyl ester

参考文献

1. Ming-Hsiu Yang, et al. J Med Chem. 2022 Jun 29. doi: 10.1021/acs.jmedchem.2c00419.

Diprovocim-X (Diprovocim X)

生物&药学活性

物理化学性质&存储条件

参考文献

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Diprovocim-X (Diprovocim X)

生物&药学活性

物理化学性质&存储条件

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