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首页-小分子抑制剂&激动剂-GPCR-mGluR-Dipraglurant
Dipraglurant

Chemical Structure : Dipraglurant

CAS No.: 872363-17-2

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Dipraglurant (ADX48621, ADX 48621)

货号: PC-49069Not For Human Use, Lab Use Only.

Dipraglurant (ADX48621) is a negative allosteric modulator (NAM) of metabotropic glutamate 5 (mGlu5) receptor with IC50 of 21 nM.

规格 价格 库存 数量
5 mg ￥2280 In stock
10 mg ￥3680 In stock
25 mg ￥5880 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Dipraglurant (ADX48621) is a negative allosteric modulator (NAM) of metabotropic glutamate 5 (mGlu5) receptor with IC50 of 21 nM.
Dipraglurant (ADX48621) shows potential for the treatment of Parkinson's disease levodopa-induced dyskinesia (PD-LID).

物理化学性质&存储条件

分子量 265.291
分子式 C16H12FN3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-fluoro-2-(4-pyridin-2-ylbut-3-ynyl)imidazo[1,2-a]pyridine

参考文献

1. Sciamanna G, et al. Neuropharmacology. 2014 Oct;85:440-50.

2. Pourmirbabaei S, et al. Eur J Pharmacol. 2019 Jul 15;855:149-159.

3. Bezard E, et al. Mov Disord. 2014 Jul;29(8):1074-9.

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