Diphyllin |CAS:22055-22-7 Probechem Biochemicals

Chemical Structure : Diphyllin

CAS No.: 22055-22-7

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Diphyllin

货号: PC-63544Not For Human Use, Lab Use Only.

Diphyllin is a naturally potent vacuolar ATPase (v-ATPase) inhibitor with IC50 of 17 nM, potently inhibits the acid influx with IC50 of 0.6 nM.

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5 mg	￥2680	In stock
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生物&药学活性

Diphyllin is a naturally potent vacuolar ATPase (v-ATPase) inhibitor with IC50 of 17 nM, potently inhibits the acid influx with IC50 of 0.6 nM.
Diphyllin dose-dependently inhibits lysosomal acidification in human osteoclasts, inhibits human osteoclastic bone resorption (IC50=14 nM), calcium release, and pit area, despite increasing TRACP activity, numbers of osteoclasts, and cell viability.
Diphyllin also inhibits the proliferation and induce the apoptosis of human gastric cancer cells.
Diphyllin shows potential antiviral for various influenza virus strains using cell-based assays, through the inhibition of endosomal acidification, thus interfering with downstream virus replication.

物理化学性质&存储条件

分子量	380.352
分子式	C21H16O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Naphtho[2,3-c]furan-1(3H)-one, 4-hydroxy-6,7-dimethoxy-9-[3,4-(methylenedioxy)phenyl]- (8CI)

参考文献

1. Sørensen MG, et al. J Bone Miner Res. 2007 Oct;22(10):1640-8.

2. Di Giorgio C, et al. Planta Med. 2005 Apr;71(4):366-9.

3. Shen W, et al. Eur J Pharmacol. 2011 Sep 30;667(1-3):330-8.

4. Chen HW, et al. Antiviral Res. 2013 Sep;99(3):371-82.

Diphyllin

生物&药学活性

物理化学性质&存储条件

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