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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Kinesin-Dimethylenastron
Dimethylenastron

Chemical Structure : Dimethylenastron

CAS No.: 863774-58-7

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Dimethylenastron (Kinesin Eg5 inhibitor)

货号: PC-45755Not For Human Use, Lab Use Only.

Dimethylenastron is a small molecule inhibitor of the mitotic kinesin Eg5.

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10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Dimethylenastron is a small molecule inhibitor of the mitotic kinesin Eg5.
Dimethylenastron inhibits endothelial cell proliferation and migration in vitro.
Dimethylenastron exhibits a shorter mitotic arrest, bipolar or multipolar karyokinesis, followed by apoptosis of the daughter cells in dimethylenastron-treated tetraploid cells.

物理化学性质&存储条件

分子量 302.3913
分子式 C16H18N2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

5(1H)-Quinazolinone, 2,3,4,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-

参考文献

1. Rello-Varona S, et al. Cell Cycle. 2009 Apr 1;8(7):1030-5.

2. Exertier P, et al. Oncotarget. 2013 Dec;4(12):2302-16.

3. Kaan HY, et al. J Med Chem. 2010 Aug 12;53(15):5676-83.

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