Dihydrotanshinone I | HuR inhibitor | Probechem Biochemicals

Chemical Structure : Dihydrotanshinone I

CAS No.: 87205-99-0

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Dihydrotanshinone I (15,16-Dihydrotanshinone I, DHTS)

货号: PC-60913Not For Human Use, Lab Use Only.

Dihydrotanshinone I (DHTS) is a natural product that prevents HuR/RNA complex formation with Ki of 3.74 nM.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

Dihydrotanshinone I (DHTS) is a natural product that prevents HuR/RNA complex formation with Ki of 3.74 nM.
Dihydrotanshinone I influences mRNA stability and translational efficiency of TNF in a HuR-dependent manner and also other functional readouts of its post-transcriptional control, such as the stability of selected pre-mRNAs in breast cancer cell lines.
Dihydrotanshinone I disrupts HuR multimerization modules and reduces tumor cell survival and proliferation, potently inhibits xenograft tumor growth in a HuR-dependent model without systemic toxicity in vivo.

物理化学性质&存储条件

分子量	278.3
分子式	C18H14O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R)-1,2-Dihydro-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione

参考文献

1. D'Agostino VG, et al. Sci Rep. 2015 Nov 10;5:16478.

2. Park JW, et al. Arch Pharm Res. 2008 Jan;31(1):47-53.

3. Filippova N, et al. J Biol Chem. 2017 Oct 13;292(41):16999-17010.

4. Lal P, et al. Nucleic Acids Res. 2017 Sep 19;45(16):9514-9527.

Dihydrotanshinone I (15,16-Dihydrotanshinone I, DHTS)

生物&药学活性

物理化学性质&存储条件

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Dihydrotanshinone I (15,16-Dihydrotanshinone I, DHTS)

生物&药学活性

物理化学性质&存储条件

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