Difopein

Chemical Structure : Difopein

CAS No.: 396834-58-5

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货号: PC-61232Not For Human Use, Lab Use Only.

Difopein is a specific, competitive inhibitor of 14-3-3/ligand interactions with high affinity.

规格	价格	库存
500 ug	￥3980	In stock
1 mg	￥5980	In stock
5 mg		Get quote
10 mg		Get quote

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生物&药学活性

Difopein is a specific, competitive inhibitor of 14-3-3/ligand interactions with high affinity.
Difopein blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S, induces apoptosis of human glioma cells through down-regulating Bcl-2, up-regulating Bax and activating caspase-9 and caspase-3, and suppresses tumor growth in mice.
Difopein also enhances the ability of cisplatin to kill cells.

物理化学性质&存储条件

分子量	6387.17
分子式	C273H424N76O89S6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	SADGAPHCVPRDLSWLDLEANMCLPGAAGLDSADGAPHCVPRDLSWLDLEANMCLPGAAGLE

参考文献

1. Masters SC, et al. J Biol Chem. 2001 Nov 30;276(48):45193-200.

2. Lalle M, et al. J Biol Chem. 2006 Feb 24;281(8):5137-48.

3. Cao W, et al. Apoptosis. 2010 Feb;15(2):230-41.

4. Foote M, et al. Biol Psychiatry. 2015 Sep 15;78(6):386-95.

Difopein

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