Difluorophenyl Quinazoline (DFPQ, AP-06-202)

Chemical Structure : Difluorophenyl Quinazoline

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货号: PC-20987Not For Human Use, Lab Use Only.

Difluorophenyl Quinazoline (DFPQ, AP-06-202) is a selective, biased, negative allosteric modulator (NAM) of β-arrestin recruitment to β2-adrenergic receptor (β2AR), without effect on on β2AR coupling to Gs.

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生物&药学活性

Difluorophenyl Quinazoline (DFPQ, AP-06-202) is a selective, biased, negative allosteric modulator (NAM) of β-arrestin recruitment to β2-adrenergic receptor (β2AR), without effect on on β2AR coupling to Gs.
DFPQ effectively inhibits agonist-promoted phosphorylation and internalization of the β2AR and protects against the functional desensitization of β-agonist mediated regulation in cell and tissue models.
Difluorophenyl Quinazoline (DFPQ) also is specific to the β2AR with minimal effects on the β1AR.

物理化学性质&存储条件

分子量	354.40
分子式	C20H20F2N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N4-cyclohexyl-N2-(3,4-difluorophenyl)quinazoline-2,4-diamine

参考文献

1. Ippolito M, et al. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2302668120.