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首页-小分子抑制剂&激动剂-Others-Other Targets-Diethyl-pythiDC
Diethyl-pythiDC

Chemical Structure : Diethyl-pythiDC

CAS No.: 1821370-70-0

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Diethyl-pythiDC (Diethyl pyimDC)

货号: PC-72921Not For Human Use, Lab Use Only.

Diethyl-pythiDC (diethyl pythiDC) is a selective, small molecule inhibitor of P4HA1, inhibits collagen biosynthesis in breast cancer cells.

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10 mg ￥1680 In stock
25 mg ￥2580 In stock
50 mg ￥4580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Diethyl-pythiDC (diethyl pythiDC) is a selective, small molecule inhibitor of P4HA1, inhibits collagen biosynthesis in breast cancer cells.
diethyl-pythiDC decreased levels of AGO2 in CRC cells, also reduced the malignant phenotypes of CRC cells, including cell proliferation, colony formation, invasion and spheroid-forming capacity.
diethyl-pythiDC (100 mg/kg) reduced growth in a CRC PDX model through the P4HA1 downstream targets, MMP1 and AGO2.
The prolyl-4-hydroxylase enzymes prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), P4HA2, and P4HB are necessary for collagen synthesis and deposition; matrix metalloproteinases degrade collagen, P4HA1 catalyzes the formation of 4-hydroxyproline from proline residues, a process that is essential for the proper folding of collagen polypeptide chains into stable triple-helical molecules.

物理化学性质&存储条件

分子量 306.336
分子式 C14H14N2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping 100 mM in DMSO (30.6mg/mL)
Solubility

Chemical Name/SMILES

6-(5-ethoxycarbonyl-thiazol-2-yl)-nicotinic acid ethyl ester

参考文献

1. James D Vasta, et al. ACS Chem Biol. 2016 Jan 15;11(1):193-9.

2. Sumit Agarwal, et al. Transl Oncol. 2020 Apr;13(4):100754.

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