Didemethylclomipramine |CAS:303-48-0 Probechem Biochemicals

Chemical Structure : Didemethylclomipramine

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Didemethylclomipramine (Norclomipramine, N-Desmethylcomipramine)

货号: PC-36045Not For Human Use, Lab Use Only.

Didemethylclomipramine (Norclomipramine, N-Desmethylcomipramine) is the major active metabolite of the tricyclic antidepressant (TCA) clomipramine.

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生物&药学活性

Didemethylclomipramine (Norclomipramine, N-Desmethylcomipramine) is the major active metabolite of the tricyclic antidepressant (TCA) clomipramine.
Didemethylclomipramine shows growth inhibition of both Mycobacterium smegmatis and M. tuberculosis cells via inhibition of Mycobacterium tuberculosis topoisomerase I (MttopoI), inhibits DNA relaxation activity of MttopoI.
Didemethylclomipramine shows MIC vales of 30 μM and 60 μM for M. smegmatis and M. tuberculosis, respectively.

物理化学性质&存储条件

分子量	300.83
分子式	C18H21ClN2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine

参考文献

1. Godbole AA, et al. Antimicrob Agents Chemother. 2015 Mar;59(3):1549-57.

2. Ekins S, et al. Tuberculosis (Edinb). 2017 Mar;103:52-60.

3. Johnson-Davis KL, et al. Methods Mol Biol. 2012;902:175-84.

Didemethylclomipramine (Norclomipramine, N-Desmethylcomipramine)

生物&药学活性

物理化学性质&存储条件

参考文献

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Didemethylclomipramine (Norclomipramine, N-Desmethylcomipramine)

生物&药学活性

物理化学性质&存储条件

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