NCI8642 | Dickkopf inhibitor | Probechem Biochemicals

Chemical Structure : Dickkopf inhibitor IIIC3

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Dickkopf inhibitor IIIC3 (Gallocyanine, NCI8642)

货号: PC-62022Not For Human Use, Lab Use Only.

NCI8642 (Gallocyanine, Dickkopf inhibitor IIIC3) is a small-molecule inhibitor of Wnt antagonist Dickkopf with EC50 of 5 uM for reversing DKK1 CM-mediated Wnt inhibition.

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生物&药学活性

NCI8642 (Gallocyanine, Dickkopf inhibitor IIIC3) is a small-molecule inhibitor of Wnt antagonist Dickkopf with EC50 of 5 uM for reversing DKK1 CM-mediated Wnt inhibition.
NCI8642 (Gallocyanine, Dickkopf inhibitor IIIC3) inhibits the binding of DKK1-alkaline phosphatase (AP) to HEK293 cells expressing the wild-type LRP5 or LRP5 mutant with IC50 of 3 uM.
NCI8642 (Gallocyanine, Dickkopf inhibitor IIIC3) reduces basal blood-glucose concentrations and improves glucose tolerance in mice.

物理化学性质&存储条件

分子量	300.27
分子式	C15H12N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(dimethylamino)-4-hydroxy-3-oxo-3H-phenoxazine-1-carboxylic acid

参考文献

1. Li X, et al. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11402-7.

Dickkopf inhibitor IIIC3 (Gallocyanine, NCI8642)

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物理化学性质&存储条件

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Dickkopf inhibitor IIIC3 (Gallocyanine, NCI8642)

生物&药学活性

物理化学性质&存储条件

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