Dichloro-all-trans-retinone | ALDH1A inhibitor | Probechem Biochemicals

Chemical Structure : Dichloro-all-trans-retinone

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Dichloro-all-trans-retinone (DAR)

货号: PC-72688Not For Human Use, Lab Use Only.

Dichloro-all-trans-retinone (DAR) is an irreversible inhibitor of retinaldehyde dehydrogenase (RALDH/ALDH1A) with IC50 of 434/55/161 nM for RALDH1/RALDH2/RALDH3.

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生物&药学活性

Dichloro-all-trans-retinone (DAR) is an irreversible inhibitor of retinaldehyde dehydrogenase (RALDH/ALDH1A) with IC50 of 434/55/161 nM for RALDH1/RALDH2/RALDH3.
Dichloro-all-trans-retinone has no activity on human mitochondrial ALDH2.
Dichloro-all-trans-retinone inhibits ATRA synthesis in a RALDH2 expressing cell line with IC50 of 3 uM.
The retinaldehyde dehydrogenase (RALDH, also ALDH1A) subfamily consists of three members, RALDH1 (ALDH1A1), RALDH2 (ALDH1A2), and RALDH3 (ALDH1A3), which synthesize all-trans-retinoic acid (ATRA) from retinaldehyde.

物理化学性质&存储条件

分子量	367.354
分子式	C21H28Cl2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3E,5E,7E,9E)-1,1-dichloro-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,5,7,9-tetraen-2-one

参考文献

1. Angelica R Harper, et al. Bioorg Med Chem. 2018 Dec 1;26(22):5766-5779.

Dichloro-all-trans-retinone (DAR)

生物&药学活性

物理化学性质&存储条件

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Dichloro-all-trans-retinone (DAR)

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物理化学性质&存储条件

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