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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-γ-secretase-Dibenzazepine
Dibenzazepine

Chemical Structure : Dibenzazepine

CAS No.: 209984-56-5

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Dibenzazepine (YO-01027)

货号: PC-22490Not For Human Use, Lab Use Only.

Dibenzazepine (YO-01027, DBZ) is a potent γ-secretase inhibitor with IC50 values of 2.92 and 2.64 nM for Notch and APPL cleavage, respectively, exhibits potent inhibiting activity against SPP in vitro and in vivo through the interaction of Val223 in SPP.

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5 mg ￥880 In stock
10 mg ￥1380 In stock
25 mg ￥2380 In stock
50 mg ￥3980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Dibenzazepine (YO-01027, DBZ) is a potent γ-secretase inhibitor with IC50 values of 2.92 and 2.64 nM for Notch and APPL cleavage, respectively, exhibits potent inhibiting activity against SPP in vitro and in vivo through the interaction of Val223 in SPP.

物理化学性质&存储条件

分子量 463.48
分子式 C26H23F2N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(2-(3,5-Difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide

参考文献

1. Groth C, et al. Mol Pharmacol. 2010 Apr;77(4):567-74.

2. Hirano J, et al. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10782-E10791.

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