Diazepinomicin |CAS 733035-26-2 Probechem Biochemicals

Chemical Structure : Diazepinomicin

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Diazepinomicin (TLN 4601, ECO-4601)

货号: PC-62205Not For Human Use, Lab Use Only.

Diazepinomicin (TLN 4601, ECO-4601) is a brain penetrant inhibitor of Ras-RAF-MAPK pathway post Ras prenylation and prior to MEK activation, binds the central and/or peripheral benzodiazepine receptors (PBR, TSPO).

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生物&药学活性

Diazepinomicin (TLN 4601, ECO-4601) is a brain penetrant inhibitor of Ras-RAF-MAPK pathway post Ras prenylation and prior to MEK activation, binds the central and/or peripheral benzodiazepine receptors (PBR, TSPO).
Diazepinomicin prevents EGF-induced phosphorylation of Raf-1, MEK, and ERK1/2.
Diazepinomicin reduces Ras-GTP levels and induces apoptosis.
Diazepinomicin shows antitumor activity and decreases tumor Raf-1 protein levels in MIA PaCa-2 tumor-bearing mice.

物理化学性质&存储条件

分子量	462.58
分子式	C28H34N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,6,8-trihydroxy-10-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one

参考文献

1. Campbell PM, et al. J Mol Signal. 2010 Nov 2;5:18.

2. Quah SY, et al. Pharmacol Ther. 2016 Jun;162:35-57.

3. Boufaied N, et al. Anticancer Drugs. 2010 Jun;21(5):543-52.

Diazepinomicin (TLN 4601, ECO-4601)

生物&药学活性

物理化学性质&存储条件

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Diazepinomicin (TLN 4601, ECO-4601)

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物理化学性质&存储条件

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