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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Estrogen Receptor/ERR-Diarylpropionitrile
Diarylpropionitrile

Chemical Structure : Diarylpropionitrile

CAS No.: 1428-67-7

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Diarylpropionitrile (DPN)

货号: PC-43041Not For Human Use, Lab Use Only.

Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β(ERβ) selective ligand, demonstrates the neuroprotective effects against 10 0M Aβ1-42-induced oxidative stress and inflammation in primary rat cortical cell culture.

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10 mg ￥1180 In stock
25 mg ￥2180 In stock
50 mg ￥3680 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β(ERβ) selective ligand agonist, demonstrates the neuroprotective effects against 10 uM Aβ1-42-induced oxidative stress and inflammation in primary rat cortical cell culture.
Diarylpropionitrile (1-100 nM) significantly decreases neuronal cell death by increasing cell viability through a significant attenuation in the reactive oxygen species level, downregulation of pro-apoptotic activated caspase-3 and Bax, and upregulation of anti-apoptotic Bcl-2; decreases the expression levels of IL-1β and IL-6; inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways.

物理化学性质&存储条件

分子量 239.2692
分子式 C15H13NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzenepropanenitrile, 4-hydroxy-α-(4-hydroxyphenyl)-

参考文献

1. Suwanna N, et al. Neurosci Lett. 2014 Aug 22;578:44-9.

2. Khalaj AJ, et al. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19125-30.

3. Mancuso M, et al. Cancer Lett. 2011 Sep 28;308(2):197-202.

4. Motylewska E, et al. Cancer Lett. 2009 Apr 8;276(1):68-73.

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