Dexpramipexole dihydrochloride |CAS:104632-27-1 Probechem Biochemicals

Chemical Structure : Dexpramipexole dihydrochloride

CAS No.: 104632-27-1

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Dexpramipexole dihydrochloride ((R)-Pramipexole;KNS-760704)

货号: PC-45174Not For Human Use, Lab Use Only.

A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively.

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50 mg	￥2400	In stock

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生物&药学活性

A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively; also possesses low/insignificant affinity (500–10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptors; used for treating Parkinson's disease (PD) and restless legs syndrome (RLS).

Alzheimer's Disease

Phase 2 Clinical

物理化学性质&存储条件

分子量	284.249
分子式	C10H19Cl2N3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 28 mg/mL
Chemical Name/SMILES	2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, hydrochloride (1:2), (6R)-

参考文献

1. Alavian KN, et al. Brain Res. 2012 Mar 29;1446:1-11.

2. Cudkowicz M, et al. Nat Med. 2011 Nov 20;17(12):1652-6.

3. Bozik ME, et al. J Clin Pharmacol. 2011 Aug;51(8):1177-85.

Dexpramipexole dihydrochloride ((R)-Pramipexole;KNS-760704)

生物&药学活性

物理化学性质&存储条件

参考文献

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Dexpramipexole dihydrochloride ((R)-Pramipexole;KNS-760704)

生物&药学活性

物理化学性质&存储条件

参考文献

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