Dexfadrostat ((R)-Fadrozole) | CYP11B2 inhibitor | Probechem Biochemicals

Chemical Structure : Dexfadrostat

CAS No.: 102676-87-9

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Dexfadrostat ((R)-Fadrozole, (R)-CGS 16949A, FAD286)

货号: PC-73413Not For Human Use, Lab Use Only.

Dexfadrostat ((R)-Fadrozole, CGS 16949A, FAD286) is a potent nonsteroidal inhibitor of aldosterone synthase (CYP 11B2, steroid 18-hydroxylase), also inhibits human placental aromatase (pIC50=6.17).

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2 mg	￥2480	In stock
5 mg	￥3980	In stock
10 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

Dexfadrostat ((R)-Fadrozole, CGS 16949A, FAD286) is a potent nonsteroidal inhibitor of aldosterone synthase (CYP 11B2, steroid 18-hydroxylase), also inhibits human placental aromatase (pIC50=6.17).
Dexfadrostat ((R)-Fadrozole, CGS 16949A, FAD286) inhibits aldosterone biosynthesis and reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.

物理化学性质&存储条件

分子量	223.279
分子式	C14H13N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzonitrile, 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]-

参考文献

1. Furet P, et al. J Med Chem. 1993;36(10):1393-1400.

2. Minnaard-Huiban M, et al. Endocrinology. 2008;149(1):28-31.

Dexfadrostat ((R)-Fadrozole, (R)-CGS 16949A, FAD286)

生物&药学活性

物理化学性质&存储条件

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Dexfadrostat ((R)-Fadrozole, (R)-CGS 16949A, FAD286)

生物&药学活性

物理化学性质&存储条件

参考文献

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