Devimistat (CPI-613)

Chemical Structure : Devimistat

CAS No.: 95809-78-2

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货号: PC-38723Not For Human Use, Lab Use Only.

CPI-613 (Devimistat) is an antimitochondrial metabolism agent that specifically induces inactivating phosphorylation of tumor cell PDH via stimulation of PDKs 1 to 4, inhibits KGDH function strongly and rapidly, selectively in tumor cells.

规格	价格	库存
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
1 g		Get quote

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生物&药学活性

CPI-613 (Devimistat) is an antimitochondrial metabolism agent that specifically induces inactivating phosphorylation of tumor cell PDH via stimulation of PDKs 1 to 4, inhibits KGDH function strongly and rapidly, selectively in tumor cells.
CPI-613 down-regulated the expression of Cyclin D3, E1, E2, F, A2, B1 and CDK2 genes of BxPC-3 pancreatic cancer cells but not non-transformed NIH-3T3 mouse fibroblast cells.
CPI-613 induced a correspondingly rapid, powerful redox signal in tumor cell mitochondria.
CPI-613 demonstrated tumor growth inhibition in human xenograft mouse models.

物理化学性质&存储条件

分子量	388.584
分子式	C22H28O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6,8-bis[(phenylmethyl)thio]-octanoic acid

参考文献

1. Stuart SD, et al. Cancer Metab. 2014 Mar 10;2(1):4.

2. Pardee TS, et al. Clin Cancer Res. 2014 Oct 15;20(20):5255-64.

3. Lee KC, et al. Ann Transl Med. 2014 Sep;2(9):91.