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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-JAK-Deucravacitinib
Deucravacitinib

Chemical Structure : Deucravacitinib

CAS No.: 1609392-27-9

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Deucravacitinib (BMS-986165, BMS 986165)

货号: PC-73037Not For Human Use, Lab Use Only.

BMS-986165 (Deucravacitinib, BMS986165) is potent, high selective allosteric inhibitor of TYK2 with Ki of 0.02 nM, IC50 of 0.2 nM.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
50 mg ￥3980 In stock
100 mg ￥5880 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-986165 (Deucravacitinib, BMS986165) is potent, high selective allosteric inhibitor of TYK2 with Ki of 0.02 nM, IC50 of 0.2 nM.
BMS-986165 binds to the TYK2 pseudokinase (JH2) domain, displays unprecedented JAK isoform and kinome selectivity.
BMS-986165 shows excellent pharmacokinetic properties with minimal profiling liabilities and is efficacious in several murine models of autoimmune disease.

物理化学性质&存储条件

分子量 425.47
分子式 C20H19D3N8O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide

参考文献

1. Wrobleski ST, et al. J Med Chem. 2019 Oct 24;62(20):8973-8995.

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