Desmethyl dabrafenib |CAS:1195765-47-9 Probechem Biochemicals

Chemical Structure : Desmethyl dabrafenib

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Desmethyl dabrafenib (GSK2167542, Dabrafenib metabolite M8)

货号: PC-35415Not For Human Use, Lab Use Only.

Desmethyl dabrafenib (GSK2167542, Dabrafenib metabolite M8) is the desmethyl- metabolic byproduct of Dabrafenib, ameliorates developmental pathologies of Kabuki Syndrome in vivo..

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Desmethyl dabrafenib (GSK2167542, Dabrafenib metabolite M8) is the desmethyl- metabolic byproduct of Dabrafenib, ameliorates developmental pathologies of Kabuki Syndrome in vivo.

物理化学性质&存储条件

分子量	505.534
分子式	C22H18F3N5O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[3-[5-(2-aminopyrimidin-4-yl)-2-propan-2-yl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide

参考文献

1. Bershas DA, et al. Drug Metab Dispos. 2013 Dec;41(12):2215-24.

2. Ouellet D, et al. J Clin Pharmacol. 2014 Jun;54(6):696-706.

3. Suttle AB, et al. J Clin Pharmacol. 2015 Apr;55(4):392-400.

4. Tsai IC, et al. Sci Rep. 2018 Jul 17;8(1):10779.

Desmethyl dabrafenib (GSK2167542, Dabrafenib metabolite M8)

生物&药学活性

物理化学性质&存储条件

参考文献

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Desmethyl dabrafenib (GSK2167542, Dabrafenib metabolite M8)

生物&药学活性

物理化学性质&存储条件

参考文献

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