Dersimelagon (MT-7117) | MC1R agonist | Probechem Biochemicals

Chemical Structure : Dersimelagon

CAS No.: 1835256-48-8

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Dersimelagon (MT-7117, MT7117)

货号: PC-35446Not For Human Use, Lab Use Only.

Dersimelagon (MT-7117) is an orally bioavailable selective, non-peptide melanocortin-1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human, cynomolgus monkey, mouse and rat MC1R, respectively.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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生物&药学活性

Dersimelagon (MT-7117) is an orally bioavailable selective, non-peptide melanocortin-1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human, cynomolgus monkey, mouse and rat MC1R, respectively.
Dersimelagon (MT-7117) shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively.
Dersimelagon (MT-7117) increases eumelanin production in a concentration-dependent manner, with EC50 of 13 pM in B16F1 cells.

物理化学性质&存储条件

分子量	675.766
分子式	C36H45F4N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-{2-[(3S,4R)-1-[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidine-3-carbonyl]-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl}piperidine-4-carboxylic acid

参考文献

1. Angelika L Erwin, et al. Diagnostics (Basel). 2021 Sep 29;11(10):1795.
2. T. Suzuki, et al. Skin Health Dis. 2022; 2(1):e78.

Dersimelagon (MT-7117, MT7117)

生物&药学活性

物理化学性质&存储条件

参考文献

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Dersimelagon (MT-7117, MT7117)

生物&药学活性

物理化学性质&存储条件

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